{Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester

Base Information

• Chemical Name: {Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester
• CAS No.: 124867-32-9
• Molecular Formula: C₂₉H₄₃NO₆
• Molecular Weight: 501.664
• Mol file: 124867-32-9.mol

Synonyms:

Chemical Property of {Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester

There total 1 articles about {Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyl-2-(2,4,5-trimethoxy-3-methylphenyl)ethylamine (113966-96-4) + butyl glyoxalate (6295-06-3) + butan-1-ol (71-36-3) → {Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester (124867-32-9)

Guidance literature:

With potassium carbonate; Ambient temperature;

DOI:10.1248/cpb.37.1493

Reference yield:

{Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester (124867-32-9) → C-(2-Benzyl-5,7,8-trimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-methylamine (124867-39-6)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / 1 h / Ambient temperature

2: 72 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

3: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 2 h / Ambient temperature

4: hydrazine monohydrate / ethanol / 2 h / Heating

With lithium aluminium tetrahydride; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.37.1493

Reference yield:

{Benzyl-[2-(2,4,5-trimethoxy-3-methyl-phenyl)-ethyl]-amino}-butoxy-acetic acid butyl ester (124867-32-9) → N-<(2-Benzyl-6-methyl-7-methoxy-5,8-dioxo-1,2,3,4,5,8-hexahydro-1-isoquinolyl)methyl>-2-oxopropanamide (124867-42-1)

Guidance literature:

Multi-step reaction with 6 steps

1: trifluoroacetic acid / 1 h / Ambient temperature

2: 72 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

3: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 2 h / Ambient temperature

4: hydrazine monohydrate / ethanol / 2 h / Heating

5: 77 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂; CCl₄ / 1 h / 25 °C

6: 1.) boron tribromide, 2.) ceric ammonium nitrate / 1.) CH₂Cl₂, - 78 deg C, 1 h, then 0 deg C, 1 h, 2.) acetonitrile-water, 0 deg C, 1 h,

With dmap; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; boron tribromide; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane;

DOI:10.1248/cpb.37.1493

upstream raw materials:

N-Benzyl-2-(2,4,5-trimethoxy-3-methylphenyl)ethylamine

butyl glyoxalate

butan-1-ol

Downstream raw materials:

Butyl 2-benzyl-5,7,8-trimethoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate

2-Benzyl-1-hydroxymethyl-6-metyl-5,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline

C-(2-Benzyl-5,7,8-trimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-methylamine

N-<(2-Benzyl-6-methyl-7-methoxy-5,8-dioxo-1,2,3,4,5,8-hexahydro-1-isoquinolyl)methyl>-2-oxopropanamide