C₂₁H₂₂N₆O₅

Base Information

• Chemical Name: C₂₁H₂₂N₆O₅
• CAS No.: 1365760-12-8
• Molecular Formula: C₂₁H₂₂N₆O₅
• Molecular Weight: 438.443
• Mol file: 1365760-12-8.mol

Synonyms:

Chemical Property of C₂₁H₂₂N₆O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₂N₆O₅

There total 8 articles about C₂₁H₂₂N₆O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

C18H18N6O4 (1365759-83-6) + propargyl alcohol (107-19-7) → C21H22N6O5 (1365760-12-8)

Guidance literature:

With copper(l) iodide; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; Darkness; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1021/co200200u

Reference yield:

tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9) → C21H22N6O5 (1365760-12-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)

1.2: Combinatorial reaction / High throughput screening (HTS)

2.1: acetic acid; zinc / dichloromethane / 0.08 h / 0 °C

3.1: tert.-butylnitrite; trimethylsilylazide / Combinatorial reaction / High throughput screening (HTS)

4.1: trifluoroacetic acid / chloroform / 0 °C / Combinatorial reaction / High throughput screening (HTS)

5.1: sodium hydride / N,N-dimethyl-formamide / Combinatorial reaction / High throughput screening (HTS)

5.2: 8 h / 0 °C / Combinatorial reaction / High throughput screening (HTS)

6.1: copper(l) iodide; acetic acid; N-ethyl-N,N-diisopropylamine / dichloromethane / Darkness; Combinatorial reaction / High throughput screening (HTS)

With copper(l) iodide; tert.-butylnitrite; trimethylsilylazide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/co200200u

Reference yield:

N-(bromoacetyl)morpholine (40299-87-4) → C21H22N6O5 (1365760-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / Combinatorial reaction / High throughput screening (HTS)

1.2: 8 h / 0 °C / Combinatorial reaction / High throughput screening (HTS)

2.1: copper(l) iodide; acetic acid; N-ethyl-N,N-diisopropylamine / dichloromethane / Darkness; Combinatorial reaction / High throughput screening (HTS)

With copper(l) iodide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/co200200u

upstream raw materials:

tert-butyl 2,4-dioxopiperidine-1-carboxylate

N-(bromoacetyl)morpholine

t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

C₁₇H₁₉N₃O₄