Azide-PEG4-Tos

Base Information

• Chemical Name: Azide-PEG4-Tos
• CAS No.: 236754-49-7
• Molecular Formula: C₁₇H₂₇N₃O₇S
• Molecular Weight: 417.483
• Mol file: 236754-49-7.mol

Synonyms:

Chemical Property of Azide-PEG4-Tos

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Azide-PEG5-Tos 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azide-PEG5-Tos is a crosslinking reagent with two functional groups. PEG spacer increases solubility in aqueous media. The azide(N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions.

Technology Process of Azide-PEG4-Tos

There total 3 articles about Azide-PEG4-Tos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

penta(ethylene glycol) bis(p-toluenesulfonate) (41024-91-3) → 14-azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate (236754-49-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield: 29.0%

→ 14-azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate (236754-49-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 4h; Inert atmosphere;

Reference yield:

Pentaethylene glycol (4792-15-8) → 14-azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate (236754-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 48 h / 20 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

Pentaethylene glycol

penta(ethylene glycol) bis(p-toluenesulfonate)

Downstream raw materials:

3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine

1,14-diazido-3,6,9,12-tetraoxatetradecane

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid