N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine

Base Information Edit

Chemical Name:N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine
CAS No.:143264-73-7
Molecular Formula:C₂₉H₃₇NO₄SSi
Molecular Weight:523.769
Hs Code.:
Mol file:143264-73-7.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine Edit

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Technology Process of N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine

There total 8 articles about N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 67-56-1
methanol

: 143264-72-6,143292-32-4
N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-hydroxypyrrolidine

: 143264-73-7,143292-30-2
N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine

Guidance literature:: With pyridinium p-toluenesulfonate; Ambient temperature;
DOI:10.1080/15257779408012166

Reference yield: 87.0%

: 143264-72-6,143292-32-4
N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-hydroxypyrrolidine

: 149-73-5
trimethyl orthoformate

: 143264-73-7,143292-30-2
N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol;
DOI:10.1016/0040-4039(92)80026-G

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 143264-73-7,143292-30-2
N-p-toluenesulphonyl(5-diphenyl-tert-butylsilyloxymethyl)-2-methoxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / imidazole, DMAP / CH₂Cl₂ / Ambient temperature

2: 75 percent / lithium hexamethyldisilazide / tetrahydrofuran / 60 h / Ambient temperature

3: 99 percent / DIBAL-H / tetrahydrofuran / 2 h / Ambient temperature

4: 89 percent / pyridinium p-toluenesulphonate / Ambient temperature

With 1H-imidazole; dmap; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1080/15257779408012166