1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide

Base Information

• Chemical Name: 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide
• CAS No.: 1130318-90-9
• Molecular Formula: C₂₆H₂₃FN₄O₅S
• Molecular Weight: 522.557
• Mol file: 1130318-90-9.mol

Synonyms:

Chemical Property of 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide

There total 14 articles about 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopropanesulphonamide (154350-29-5) + C23H16FN3O3 → 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide (1130318-90-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 70 ℃; for 1.5h;

DOI:10.1021/ml400192w

Reference yield:

C24H20FN3O4 (1361147-56-9) → 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide (1130318-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 75 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 90 °C

With hydrogenchloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/jm201322r

Reference yield:

C26H24FN3O4 (1361147-77-4) → 1-[[5-(aminocarbonyl)-2-fluorophenyl]methyl]-N-(cyclopropylsulfonyl)-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-methyl-1H-indole-2-carboxamide (1130318-90-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 70 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 75 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 90 °C

With hydrogenchloride; 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/jm201322r

upstream raw materials:

C₂₄H₂₀FN₃O₄

C₂₆H₂₄FN₃O₄

C₁₃H₁₄INO₂

C₁₉H₂₀N₂O₃