1-[9-(4-chlorophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]ethanone

Base Information

• Chemical Name: 1-[9-(4-chlorophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]ethanone
• CAS No.: 470456-21-4
• Molecular Formula: C₂₄H₂₀ClN₅OS
• Molecular Weight: 461.975
• Mol file: 470456-21-4.mol

Synonyms:

Chemical Property of 1-[9-(4-chlorophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[9-(4-chlorophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]ethanone

There total 6 articles about 1-[9-(4-chlorophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,7-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

acetylacetone (123-54-6,81235-32-7) + 1-[9-(4-Chloro-phenyl)-4-hydrazino-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-15-6) → 1-[9-(4-Chloro-phenyl)-4-(3,5-dimethyl-pyrazol-1-yl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-21-4)

Guidance literature:

for 4h; Heating;

DOI:10.1002/jccs.200200035

Reference yield:

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione (103868-29-7) → 1-[9-(4-Chloro-phenyl)-4-(3,5-dimethyl-pyrazol-1-yl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-21-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / CH₃CO₂Na*3H₂O / ethanol / 2 h / Heating

2: 92 percent / NaOEt / ethanol / 0.33 h / Heating

3: 30 percent / 8 h / Heating

4: 77 percent / POCl₃ / 4 h / Heating

5: 91 percent / hydrazine hydrate / ethanol / 2 h / Heating

6: 83 percent / 4 h / Heating

With sodium ethanolate; sodium acetate; hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1002/jccs.200200035

Reference yield:

2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide (470455-87-9) → 1-[9-(4-Chloro-phenyl)-4-(3,5-dimethyl-pyrazol-1-yl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone (470456-21-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / NaOEt / ethanol / 0.33 h / Heating

2: 30 percent / 8 h / Heating

3: 77 percent / POCl₃ / 4 h / Heating

4: 91 percent / hydrazine hydrate / ethanol / 2 h / Heating

5: 83 percent / 4 h / Heating

With sodium ethanolate; hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1002/jccs.200200035

upstream raw materials:

acetylacetone

1-[9-(4-Chloro-phenyl)-4-hydrazino-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione

2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetamide