C₂₁H₂₃BO₃

Base Information

• Chemical Name: C₂₁H₂₃BO₃
• CAS No.: 1422960-89-1
• Molecular Formula: C₂₁H₂₃BO₃
• Molecular Weight: 334.223
• Mol file: 1422960-89-1.mol

Synonyms:

Chemical Property of C₂₁H₂₃BO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₃BO₃

There total 6 articles about C₂₁H₂₃BO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C23H27BO4 (1422961-05-4) → C21H23BO3 (1422960-89-1)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; Inert atmosphere; Reflux;

DOI:10.1021/jo302656s

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) → C21H23BO3 (1422960-89-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / methanol; water / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / toluene / 48 h / Inert atmosphere; Reflux; Dean-Stark

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / acetone / Inert atmosphere; Reflux

With n-butyllithium; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; acetone; toluene;

DOI:10.1021/jo302656s

Reference yield:

benzaldehyde (100-52-7) → C21H23BO3 (1422960-89-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / methanol; water / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / toluene / 48 h / Inert atmosphere; Reflux; Dean-Stark

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / acetone / Inert atmosphere; Reflux

With n-butyllithium; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; acetone; toluene;

DOI:10.1021/jo302656s

upstream raw materials:

2-bromophenyl methyl ketone

benzaldehyde

(E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one

C₁₇H₁₅BrO₂

Downstream raw materials:

(R)-3-phenyl-2,3-dihydro-1H-inden-1-one

(S)-3-phenyl-2,3-dihydro-1H-inden-1-one

Refernces