5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite
• CAS No.: 108787-36-6
• Molecular Formula: C₄₅H₅₃N₄O₁₀P
• Molecular Weight: 840.91
• Mol file: 108787-36-6.mol

Synonyms:

Chemical Property of 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite

There total 4 articles about 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane (108787-34-4) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite (108787-36-6,108787-38-8,136378-68-2)

Guidance literature:

With 1H-tetrazole; In 1,4-dioxane; acetonitrile; at 20 ℃; for 1h;

Reference yield: 82.0%

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2) → 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite (108787-36-6,108787-38-8,136378-68-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxythymidine phosphoramidite (108787-36-6,108787-38-8,136378-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Et₃N / diethyl ether / 16 h / Ambient temperature

2: 67 percent / tetrazol / acetonitrile / 0.5 h

With 1H-tetrazole; triethylamine; In diethyl ether; acetonitrile;

DOI:10.1080/15257779408013207

upstream raw materials:

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane

5'-O-(4-4'-dimethoxytrityl)thymidine

2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

2-(4-nitrophenyl)ethanol

Downstream raw materials:

C₇₀H₆₅N₈O₁₆PS