isocotoin

Base Information

• Chemical Name: isocotoin
• CAS No.: 81525-12-4
• Molecular Formula: C14H12 O4
• Molecular Weight: 0
• Mol file: 81525-12-4.mol

Synonyms:2,4-Dihydroxy-6-methoxybenzophenone;Isocotoin

Chemical Property of isocotoin

Chemical Property:

• Melting Point: 162°C
• PSA: 66.76000
• LogP: 2.33740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isocotoin

There total 2 articles about isocotoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxyresorcinol (2174-64-3) + benzoyl chloride (98-88-4) → cotoin (479-21-0) + 2,4-Dihydroxy-6-methoxybemzophenone (81525-12-4)

Guidance literature:

With aluminium trichloride; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1248/cpb.44.1744

Reference yield:

5-methoxyresorcinol (2174-64-3) + benzonitrile (100-47-0) → 2,4-Dihydroxy-6-methoxybemzophenone (81525-12-4)

Guidance literature:

With diethyl ether; zinc(II) chloride; Durch Kochen des entstandenen Ketimidhydrochlorids mit Wasser;

Reference yield: 35.0%

2,4-Dihydroxy-6-methoxybemzophenone (81525-12-4) + isoprene (78-79-5,9003-31-0) → 6-benzoyl-7-hydroxy-5-methoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (81490-47-3) + 8-Benzoyl-5-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran (64620-23-1) + 6-benzoyl-5-methoxy-3,4,9,10-tetrahydro-2,2,8,8-tetramethyl-2H,8H-benzo<1,2-b;3,4-b'>dipyran (76444-58-1)

Guidance literature:

With phosphoric acid; In xylene; at 30 - 35 ℃; for 12h;

DOI:10.1055/s-1983-30356

upstream raw materials:

5-methoxyresorcinol

benzonitrile

benzoyl chloride

Downstream raw materials:

2,4-dihydroxy-6-methoxy-3,5-di-(3'-methylbut-2'-enyl)-benzophenone

2,4-dihydroxy-6-methoxy-5-(3'-methylbut-2'-enyl)-benzophenone

2,4-dihydroxy-6-methoxy-3-(3'-methylbut-2'-enyl)-benzophenone

6-benzoyl-7-hydroxy-5-methoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran

Refernces