4,4'-diisopropoxy-1,1'-biphenyl

Base Information

• Chemical Name: 4,4'-diisopropoxy-1,1'-biphenyl
• CAS No.: 128836-59-9
• Molecular Formula: C₁₈H₂₂O₂
• Molecular Weight: 270.371
• Mol file: 128836-59-9.mol

Synonyms:

Chemical Property of 4,4'-diisopropoxy-1,1'-biphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-diisopropoxy-1,1'-biphenyl

There total 20 articles about 4,4'-diisopropoxy-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tri(p-isopropoxyphenyl)bismuth (95149-18-1) + phenylacetyl chloride (103-80-0) → 1-(4-isopropoxyphenyl)-2-phenylethanone (69342-32-1) + 4,4'-Diisopropoxy-biphenyl (128836-59-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; at 80 ℃; for 3h; Schlenk tube; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.08.074

Reference yield: 86.0%

tri(p-isopropoxyphenyl)bismuth (95149-18-1) + 3-bromo-2-oxo-2H-benzo[h]chromen-4-yl trifluoromethanesulfonate → 3-bromo-4-(4-isopropoxyphenyl)-2H-benzo[h]chromen-2-one + 4,4'-Diisopropoxy-biphenyl (128836-59-9)

Guidance literature:

With trans-diacetylpalladium(II) bis(dicyclohexylamine); sodium hydrogencarbonate; In N,N-dimethyl acetamide; at 90 ℃; for 2h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2015.05.060

Reference yield: 84.0%

tri(p-isopropoxyphenyl)bismuth (95149-18-1) + 2-(2,2-dibromovinyl)thiophene (77295-66-0) → (p-isopropoxyphenyl)(2-thienyl)acetylene (1224169-07-6) + 4,4'-Diisopropoxy-biphenyl (128836-59-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol1004164

upstream raw materials:

1-bromo-4-isopropoxybenzene

3-chloroprop-1-ene

4-bromo-phenol

tri(p-isopropoxyphenyl)bismuth

Refernces

• 1、 Rao, Maddali L. N.,Jadhav, Deepak N.,Dasgupta, Priyabrata. "Pd-catalyzed tandem chemoselective synthesis of 2-arylbenzofurans using threefold arylating triarylbismuth reagents". . p. 781 - 788. Retrieved 2013/03/13.
• 2、 Rao, Maddali L. N.,Jadhav, Deepak N.,Dasgupta, Priyabrata. "Pd-catalyzed domino synthesis of internal alkynes using triarylbismuths as multicoupling organometallic nucleophiles". supporting information; experimental part. p. 2048 - 2051. Retrieved 2010/07/03.