D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt

Base Information

• Chemical Name: D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt
• CAS No.: 128441-63-4
• Molecular Formula: C₆H₁₃O₉P*C₁₂H₂₃N
• Molecular Weight: 441.459
• Mol file: 128441-63-4.mol

Synonyms:

Chemical Property of D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt

There total 12 articles about D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-3,4:5.6-di-O-cyclohexylidene-2-O-methyl-(-)-chiro-inositol (6848-53-9) → D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt (128441-63-4)

Guidance literature:

Multi-step reaction with 12 steps

1: 1) Ac₂O, DMSO 2) LiBH₄ / 1) CH₂Cl₂, 8h, reflux 2) THF, 20 min, -78 deg C

2: 88 percent / Et₃N, DMAP / CH₂Cl₂ / 0 °C

3: 83 percent / AlCl₃, NaI / acetonitrile / Ambient temperature

4: 99 percent / Et₃N, DMAP / CH₂Cl₂

5: 96 percent / CF₃CO₂H / methanol / Ambient temperature

6: 100 percent / pyridine / 0 °C

7: 93 percent / Et₃N, DMAP / CH₂Cl₂

8: 100 percent / p-TsOH / aq. acetic acid

9: 1) 1H-Tetrazole 2) H₂O / 1) CH₂Cl₂

10: m-CPBA

11: H₂ / 10percent Pd/C / methanol

12: NaOMe / methanol / Ambient temperature

With pyridine; 1H-tetrazole; dmap; lithium borohydride; aluminium trichloride; water; hydrogen; sodium methylate; acetic anhydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; acetic acid; acetonitrile;

DOI:10.1016/S0040-4039(00)88825-5

Reference yield:

D-3,4,5,6-tetra-O-benzoyl-myo-inositol (128442-41-1) → D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt (128441-63-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 percent / pyridine / 0 °C

2: 93 percent / Et₃N, DMAP / CH₂Cl₂

3: 100 percent / p-TsOH / aq. acetic acid

4: 1) 1H-Tetrazole 2) H₂O / 1) CH₂Cl₂

5: m-CPBA

6: H₂ / 10percent Pd/C / methanol

7: NaOMe / methanol / Ambient temperature

With pyridine; 1H-tetrazole; dmap; water; hydrogen; sodium methylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;

DOI:10.1016/S0040-4039(00)88825-5

Reference yield:

D-3-O-benzoyl-1,2-O-cyclohexylidene-myo-inositol (131432-86-5) → D-(+)-myo-inositol 1-phosphate bis(cyclohexylammonium) salt (128441-63-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 99 percent / Et₃N, DMAP / CH₂Cl₂

2: 96 percent / CF₃CO₂H / methanol / Ambient temperature

3: 100 percent / pyridine / 0 °C

4: 93 percent / Et₃N, DMAP / CH₂Cl₂

5: 100 percent / p-TsOH / aq. acetic acid

6: 1) 1H-Tetrazole 2) H₂O / 1) CH₂Cl₂

7: m-CPBA

8: H₂ / 10percent Pd/C / methanol

9: NaOMe / methanol / Ambient temperature

With pyridine; 1H-tetrazole; dmap; water; hydrogen; sodium methylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;

DOI:10.1016/S0040-4039(00)88825-5

upstream raw materials:

C₄₁H₃₃O₁₄P

L-3,4:5.6-di-O-cyclohexylidene-2-O-methyl-(-)-chiro-inositol

D-3,4,5,6-tetra-O-benzoyl-myo-inositol

D-3-O-benzoyl-1,2-O-cyclohexylidene-myo-inositol