5-methyl-1H-indole-3-acetic acid ethyl e

Base Information

• Chemical Name: 5-methyl-1H-indole-3-acetic acid ethyl e
• CAS No.: 91957-21-0
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.268
• Mol file: 91957-21-0.mol

Synonyms:

Chemical Property of 5-methyl-1H-indole-3-acetic acid ethyl e

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(5-Methyl-3-indolyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-1H-indole-3-acetic acid ethyl e

There total 7 articles about 5-methyl-1H-indole-3-acetic acid ethyl e which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl bromide (74-96-4) + 2-(5-methyl-1H-indol-3-yl)acetic acid (1912-47-6) → 5-methyl-1H-indole-3-acetic acid ethyl e (91957-21-0)

Guidance literature:

2-(5-methyl-1H-indol-3-yl)acetic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl bromide; In N,N-dimethyl-formamide; for 4h; Reflux;

Reference yield: 82.0%

C13H13NO2(2-) → 5-methyl-1H-indole-3-acetic acid ethyl e (91957-21-0)

Guidance literature:

With iron(III) tris(2,2,6,6-tetramethyl-3,5-heptanedionate); phenylsilane; In 1,2-dichloro-ethane; isopropyl alcohol; at 35 ℃; for 2h;

DOI:10.1039/d1sc03058b

Reference yield: 82.0%

(2E,4E)-4-[2-(4-methylphenyl)hydrazono]-2-butenoic acid ethyl ester → 5-methyl-1H-indole-3-acetic acid ethyl e (91957-21-0)

Guidance literature:

With tert-Butyl iodide; In acetonitrile; for 0.5h; Reflux;

DOI:10.1002/chem.201504010

upstream raw materials:

4-oxo-but-2-enoic acid ethyl ester

p-tolylhydrazine hydrochloride

diazoacetic acid ethyl ester

5-methyl-1H-indole