methyl 3-chloro-2-(trifluoromethyl)isonicotinate

Base Information

• Chemical Name: methyl 3-chloro-2-(trifluoromethyl)isonicotinate
• CAS No.: 1034132-07-4
• Molecular Formula: C₈H₅ClF₃NO₂
• Molecular Weight: 239.581
• Mol file: 1034132-07-4.mol

Synonyms:

Chemical Property of methyl 3-chloro-2-(trifluoromethyl)isonicotinate

Chemical Property:

Purity/Quality:

Methyl 3-chloro-2-(trifluoromethyl)isonicotinate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-chloro-2-(trifluoromethyl)isonicotinate

There total 2 articles about methyl 3-chloro-2-(trifluoromethyl)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + 3-chloro-2-(trifluoromethyl)pyridine-4-carboxylic acid (749875-02-3) → methyl 3-chloro-2-(trifluoromethyl)isonicotinate (1034132-07-4)

Guidance literature:

3-chloro-2-(trifluoromethyl)pyridine-4-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

methanol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

diazomethyl-trimethyl-silane (18107-18-1) + 3-chloro-2-(trifluoromethyl)pyridine-4-carboxylic acid (749875-02-3) → methyl 3-chloro-2-(trifluoromethyl)isonicotinate (1034132-07-4)

Guidance literature:

With methanol; In hexanes; toluene; at 20 ℃; for 1h;

Reference yield:

methyl 3-chloro-2-(trifluoromethyl)isonicotinate (1034132-07-4) → ethyl 4-hydroxy-1-methyl-2-oxo-6-phenyl-8-(trifluoromethyl)-1,2-dihydro-1,7-naphthyridine-3-carboxylate (1034132-12-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 20 - 60 °C

2.1: N-Bromosuccinimide / acetic acid / acetonitrile / 24 h / 50 °C

3.1: potassium carbonate / dichloromethane / 4.33 h / 20 - 80 °C

4.1: ethanol; sodium / 1 h / 20 °C

4.2: 20 °C / pH 7

5.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / ethanol / 3 h / 20 - 80 °C

With N-Bromosuccinimide; ethanol; sodium; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic acid; XPhos; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

upstream raw materials:

diazomethyl-trimethyl-silane

3-chloro-2-(trifluoromethyl)pyridine-4-carboxylic acid

methanol

Downstream raw materials:

ethyl 4-hydroxy-1-methyl-2-oxo-6-phenyl-8-(trifluoromethyl)-1,2-dihydro-1,7-naphthyridine-3-carboxylate