Technology Process of ethyl (8-hydroxy-1-oxo-2,3-dihydro-1H-cyclopenta[a]naphthalen-2-yl)acetate
There total 9 articles about ethyl (8-hydroxy-1-oxo-2,3-dihydro-1H-cyclopenta[a]naphthalen-2-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 0.75 h / 200 - 210 °C
2: 94 percent / HF / 90 h / Ambient temperature
3: 1.) sodium ethoxide / 1.) benzene, 1 h. 2.) benzene, 24 h
4: 1.) sodium ethoxide / 1.) benzene, 2 h, 2.) DMF, 100 deg C, 20 h
5: 48percent HBr, glacial acetic acid / 120 h / Heating
6: H2SO4
With
sulfuric acid; hydrogen fluoride; hydrogen bromide; sodium ethanolate; acetic acid;
DOI:10.1021/jm00179a008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) sodium ethoxide / 1.) benzene, 1 h. 2.) benzene, 24 h
2: 1.) sodium ethoxide / 1.) benzene, 2 h, 2.) DMF, 100 deg C, 20 h
3: 48percent HBr, glacial acetic acid / 120 h / Heating
4: H2SO4
With
sulfuric acid; hydrogen bromide; sodium ethanolate; acetic acid;
DOI:10.1021/jm00179a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / HF / 90 h / Ambient temperature
2: 1.) sodium ethoxide / 1.) benzene, 1 h. 2.) benzene, 24 h
3: 1.) sodium ethoxide / 1.) benzene, 2 h, 2.) DMF, 100 deg C, 20 h
4: 48percent HBr, glacial acetic acid / 120 h / Heating
5: H2SO4
With
sulfuric acid; hydrogen fluoride; hydrogen bromide; sodium ethanolate; acetic acid;
DOI:10.1021/jm00179a008
