8-Quinolinol, 5,7-dichloro-2-((dimethylamino)methyl)-

Base Information

Chemical Name:8-Quinolinol, 5,7-dichloro-2-((dimethylamino)methyl)-
CAS No.:747408-78-2
Molecular Formula:C₁₂H₁₂Cl₂N₂O
Molecular Weight:271.146
Hs Code.:
UNII:Q7K6GJQ4O4
DSSTox Substance ID:DTXSID701029571
Nikkaji Number:J3.490.091D
Wikipedia:PBT2
Wikidata:Q7118446
Metabolomics Workbench ID:149518
ChEMBL ID:CHEMBL3634131
Mol file:747408-78-2.mol

Synonyms:5,7-dichloro-2-((dimethylamino)methyl)-8-hydroxyquinoline;PBT2 compound

Suppliers and Price of 8-Quinolinol, 5,7-dichloro-2-((dimethylamino)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 8-Quinolinol, 5,7-dichloro-2-((dimethylamino)methyl)-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:270.0326684
Heavy Atom Count:17
Complexity:265

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
Recent ClinicalTrials:Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease
Recent EU Clinical Trials:A 12-Week randomised, double-blind, placebo-controlled, parallel three-group study to assess the safety, tolerability and efficacy of two dose levels of PBT2 to slow progression of disease in patients with early Alzheimer’s disease

Technology Process of 8-Quinolinol, 5,7-dichloro-2-((dimethylamino)methyl)-

There total 2 articles about 8-Quinolinol, 5,7-dichloro-2-((dimethylamino)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.5%

: tert-butyl (5,7-dichloro-2-formylquinolin-8-yl)carbonate

: 124-40-3
dimethyl amine

: 747408-78-2
PBT2

Guidance literature:: tert-butyl (5,7-dichloro-2-formylquinolin-8-yl)carbonate; dimethyl amine; With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 2h;

With sodium tetrahydroborate; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acs.molpharmaceut.7b00936