N-(4-methoxy-2-nitrophenyl)benzamide

Base Information

• Chemical Name: N-(4-methoxy-2-nitrophenyl)benzamide
• CAS No.: 38259-63-1
• Molecular Formula: C14H12 N2 O4
• Molecular Weight: 272.26
• NSC Number: 120199
• DSSTox Substance ID: DTXSID50298011
• Wikidata: Q82039558
• ChEMBL ID: CHEMBL1563642
• Mol file: 38259-63-1.mol

Synonyms:N-(4-methoxy-2-nitrophenyl)benzamide;38259-63-1;NSC120199;Oprea1_037555;MLS001033067;CHEMBL1563642;DTXSID50298011;HMS2708B08;STK044250;AKOS001044940;NSC-120199;SMR000385469;AB00610931-02;Z56871773

Chemical Property of N-(4-methoxy-2-nitrophenyl)benzamide

Chemical Property:

• Vapor Pressure: 1.83E-05mmHg at 25°C
• Boiling Point: 363.2°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.333g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 272.07970687
• Heavy Atom Count: 20
• Complexity: 350

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)NC(=O)C2=CC=CC=C2)[N+](=O)[O-]

Technology Process of N-(4-methoxy-2-nitrophenyl)benzamide

There total 7 articles about N-(4-methoxy-2-nitrophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(p-methoxyphenyl)benzamide (7472-54-0) → N-(4-methoxy-2-nitrophenyl)benzamide (38259-63-1)

Guidance literature:

With dipotassium peroxodisulfate; copper(II) nitrate trihydrate; In acetonitrile; at 82 ℃; for 8h; regioselective reaction;

DOI:10.1016/j.tetlet.2020.152223

Reference yield: 93.0%

benzoyl chloride (98-88-4) + 4-methoxy-benzylamine (2393-23-9) → N-(4-methoxy-2-nitrophenyl)benzamide (38259-63-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;

DOI:10.1002/ejoc.201900463

Reference yield: 90.0%

N-(4-Methoxy-phenyl)-benzimidoyl chloride (34918-74-6) → N-(4-methoxy-2-nitrophenyl)benzamide (38259-63-1)

Guidance literature:

With silver nitrate; In acetonitrile; for 0.5h;

upstream raw materials:

N-(p-methoxyphenyl)benzamide

benzoyl chloride

4-methoxy-2-nitroaniline

N-(4-Methoxy-phenyl)-benzimidoyl chloride

Downstream raw materials:

4-methoxy-2-nitroaniline

N-benzoyl-4-methoxy-1,2-phenylenediamine