Amlodipine 2-Phthalimide

Base Information

Chemical Name:Amlodipine 2-Phthalimide
CAS No.:140171-49-9
Molecular Formula:C29H29ClN2O7
Molecular Weight:553.011
Hs Code.:
UNII:FVJ6MSB8KG
Mol file:140171-49-9.mol

Synonyms:Amlodipine 2-Phthalimide;140171-49-9;FVJ6MSB8KG;SCHEMBL4990358;NTVITRUDLZBADK-UHFFFAOYSA-N;3,5-Diethyl 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate;3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-1,4-dihydro-6-methyl-, 3,5-diethyl ester;3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-1,4-dihydro-6-methyl-, diethyl ester;Diethyl 4-(2-chlorophenyl)-2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethoxy]methyl}-6-methyl-1,4-dihydro-3,5-pyridine dicarboxylate;Diethyl 4-(2-chlorophenyl)-2-{[2-(1,3-dioxo-1.3-dihydro-2H-isoindol-2-yl)ethoxy]methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate;Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo- 1.3-dihydro-2H-isoindol-2-yl) ethoxy]methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate;Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo-1.3-dihydro-2H-isoindol-2-yl) ethoxy] methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate;Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo-1.3-dihydro-2H-isoindol-2-yl) ethoxy]methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate;Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo-1.3-dihydro-2H-isoindol-2-yl)ethoxy]methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate

Suppliers and Price of Amlodipine 2-Phthalimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Amlodipine 2-Phthalimide

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:552.1663290
Heavy Atom Count:39
Complexity:1010

Purity/Quality:: >95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OCC)COCCN3C(=O)C4=CC=CC=C4C3=O)C

Technology Process of Amlodipine 2-Phthalimide

There total 3 articles about Amlodipine 2-Phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 89-98-5
2-chloro-benzaldehyde

: 626-34-6
ethyl 3-aminobut-2-enoate

: 88150-75-8
ethyl 4-[2-(phthalimido)ethoxy]acetoacetate

: 140171-49-9
Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo-1.3-dihydro-2H-isoindol-2-yl) ethoxy] methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate

Guidance literature:: Heating;
DOI:10.1016/0223-5234(91)90132-7

Reference yield:

: ethyl 4-(2-phthalimidoethoxy)-2-(2'-chlorobenzylidene)-acetoacetate

: 626-34-6,7318-00-5,41867-20-3
ethyl aminocrotonate

: 140171-49-9
Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo-1.3-dihydro-2H-isoindol-2-yl) ethoxy] methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate

Guidance literature:: In ethanol; acetic acid; isopropyl alcohol;

Reference yield:

: 141-97-9
ethyl acetoacetate

: 140171-49-9
Diethyl 4-(2-chlorophenyl)-2-{[2-(1.3-dioxo-1.3-dihydro-2H-isoindol-2-yl) ethoxy] methyl}-6-methyl-1.4-dihydro-3.5-pyridine dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / ethanol

2: 35 percent / Heating

With ammonia; In ethanol;
DOI:10.1016/0223-5234(91)90132-7