3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy] methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy] methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester
CAS No.:140171-51-3
Molecular Formula:C₃₀H₃₁ClN₂O₇
Molecular Weight:567.038
Hs Code.:

3,5-Pyridinedicarboxylic acid,
4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]
methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester

Synonyms:

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy] methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy] methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester

Chemical Property:

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Safty Information:

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Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy] methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester

There total 4 articles about 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy] methyl]-1,4-dihydro-6-methyl-, 3-(1,1-dimethylethyl) 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 89-98-5
2-chloro-benzaldehyde

: 21731-17-9
methyl 3-aminocrotonate

: 140171-93-3
tert-butyl 4-<2-(phthalimido)ethoxy>acetoacetate

: 140171-51-3
4-(2-Chloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Guidance literature:: Heating;
DOI:10.1016/0223-5234(91)90132-7

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 140171-51-3
4-(2-Chloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / ethanol

2: 20 percent / Heating

With ammonia; In ethanol;
DOI:10.1016/0223-5234(91)90132-7

Reference yield:

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: 140171-51-3
4-(2-Chloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / 1.) THF, RT, 1 h, 2.) THF, RT, 18 h

2: 20 percent / Heating

With sodium hydride;
DOI:10.1016/0223-5234(91)90132-7