1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone

Base Information

• Chemical Name: 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone
• CAS No.: 82652-17-3
• Molecular Formula: C₉H₉FO₃S
• Molecular Weight: 216.233
• Hs Code.: 2914790090
• Mol file: 82652-17-3.mol

Synonyms:

Chemical Property of 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone

Chemical Property:

• Melting Point: 111-113°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Fluorophenyl)-2-(methylsulfonyl)-1-ethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone

There total 12 articles about 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

para-fluorostyrene (405-99-2) + sodium methansulfinate (20277-69-4) → 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone (82652-17-3)

Guidance literature:

With copper dichloride; In acetic acid; at 60 ℃; for 6h;

DOI:10.1016/j.tetlet.2020.152794

Reference yield: 75.0%

1-fluoro-4-((E)-1-iodo-2-(methylsulfonyl)vinyl)benzene → 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone (82652-17-3)

Guidance literature:

With sodium acetate; In water; dimethyl sulfoxide; at 90 ℃; for 5h;

DOI:10.1021/acs.joc.9b02302

Reference yield: 74.0%

para-fluorostyrene (405-99-2) + dimethyl sulfoxide (67-68-5,8070-53-9) → 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone (82652-17-3)

Guidance literature:

With oxygen; phosphonic acid diethyl ester; copper(I) bromide; at 90 ℃; for 12h; under 760.051 Torr;

DOI:10.1039/c4sc01901f

upstream raw materials:

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

methanesulfonyl chloride

1-(4-fluorophenyl)ethanone

sodium methansulfinate

Downstream raw materials:

5-[(2,6-diethyl-4-methylphenyl)carbonyl]-3-(4-fluorophenyl)-1-methyl-4-methylsulfonyl-1H-pyrazole

4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone