Acetamox

Base Information

• Chemical Name: Acetamox
• CAS No.: 8017-69-4
• Molecular Formula: C₄H₆N₄O₃S₂
• Molecular Weight: 222.249
• Mol file: 8017-69-4.mol

Synonyms:

Chemical Property of Acetamox

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamox

There total 7 articles about Acetamox which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-amino-1, 3, 4-thiadiazole-2-sulfonamide (14949-00-9) + tiolacetic acid (507-09-5) → acetazolamide (59-66-5,8017-69-4)

Guidance literature:

With 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate; In acetonitrile; at 20 ℃; for 5h; Irradiation;

DOI:10.1021/acs.orglett.9b03905

Reference yield: 74.0%

5-acetamido-1,3,4-thiadiazolyl-2-sulfonyl chloride (32873-57-7) → acetazolamide (59-66-5,8017-69-4)

Guidance literature:

With 1,1,1-triphenylsilylamine; In acetonitrile; for 1h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.034

Reference yield:

2-acetylamino-5-benzylmercapto-1,3,4-thiadiazole (64387-67-3) → acetazolamide (59-66-5,8017-69-4)

Guidance literature:

With chlorine; acetic acid; anschliessendes Behandeln mit fluessigem NH₃;

DOI:10.1021/ja01599a033

upstream raw materials:

5-acetamido-1,3,4-thiadiazolyl-2-sulfonyl chloride

2-acetylamino-5-benzylmercapto-1,3,4-thiadiazole

PSA

PPA

Downstream raw materials:

N-(5-oxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-acetamide

1-(5-acetylamino-[1,3,4]thiadiazole-2-sulfonyl)-3-(2-cyano-ethyl)-3-p-tolyl-triazene

C₁₁H₁₀N₄O₄S₂

C₁₁H₁₁N₅O₄S₂