O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate

Base Information

• Chemical Name: O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate
• CAS No.: 1438853-60-1
• Molecular Formula: C₁₂H₁₂BrClN₅O₄PS
• Molecular Weight: 468.655
• Mol file: 1438853-60-1.mol

Synonyms:

Chemical Property of O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate

There total 8 articles about O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chloro-2-pyridyl)hydrazine (22841-92-5) → O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate (1438853-60-1)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium ethanolate / ethanol / Reflux

2: trichlorophosphate / acetonitrile / 80 °C

3: dipotassium peroxodisulfate; sulfuric acid / acetonitrile / Reflux

4: sodium hydroxide / water; methanol

5: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

6: ammonium hydroxide / water; tetrahydrofuran / 0 °C

7: 1,2-dichloro-ethane / 2 h / Reflux

8: monoethylene glycol diethyl ether / Reflux

With ammonium hydroxide; dipotassium peroxodisulfate; oxalyl dichloride; sulfuric acid; sodium ethanolate; N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; monoethylene glycol diethyl ether; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jf4012467

Reference yield:

2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester (500011-88-1) → O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate (1438853-60-1)

Guidance literature:

Multi-step reaction with 7 steps

1: trichlorophosphate / acetonitrile / 80 °C

2: dipotassium peroxodisulfate; sulfuric acid / acetonitrile / Reflux

3: sodium hydroxide / water; methanol

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

5: ammonium hydroxide / water; tetrahydrofuran / 0 °C

6: 1,2-dichloro-ethane / 2 h / Reflux

7: monoethylene glycol diethyl ether / Reflux

With ammonium hydroxide; dipotassium peroxodisulfate; oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; monoethylene glycol diethyl ether; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jf4012467

Reference yield:

ethyl 5-chloro-2-(3-chloropyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylate (500011-89-2) → O,O-dimethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonylcarbamoylphosphoramidothioate (1438853-60-1)

Guidance literature:

Multi-step reaction with 6 steps

1: dipotassium peroxodisulfate; sulfuric acid / acetonitrile / Reflux

2: sodium hydroxide / water; methanol

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

4: ammonium hydroxide / water; tetrahydrofuran / 0 °C

5: 1,2-dichloro-ethane / 2 h / Reflux

6: monoethylene glycol diethyl ether / Reflux

With ammonium hydroxide; dipotassium peroxodisulfate; oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; monoethylene glycol diethyl ether; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jf4012467

upstream raw materials:

3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

O,O-dimethyl phosphoramidothioate

(3-chloro-2-pyridyl)hydrazine

2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester

Refernces