8-propylquinoline

Base Information

• Chemical Name: 8-propylquinoline
• CAS No.: 7661-53-2
• Molecular Formula: C₁₂H₁₃N
• Molecular Weight: 171.242
• Mol file: 7661-53-2.mol

Synonyms:

Chemical Property of 8-propylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-propylquinoline

There total 3 articles about 8-propylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

8-bromoquinoline (16567-18-3) + 1-(pyridin-2-yl)butan-1-one (22971-32-0) → 8-propylquinoline (7661-53-2)

Guidance literature:

With 2.9-dimethyl-1,10-phenanthroline; palladium(II) trifluoroacetate; potassium tert-butylate; In toluene; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02498

Reference yield: 90.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + 2-propylaniline (1821-39-2) → 8-propylquinoline (7661-53-2)

Guidance literature:

With sulfuric acid; potassium iodide; In water; at 145 ℃; for 15h;

DOI:10.1246/bcsj.20190263

Reference yield:

8-bromoquinoline (16567-18-3) + n-propylmagnesium bromide (927-77-5) → 8-propylquinoline (7661-53-2)

Guidance literature:

With [1,3-bis(diphenylphosphino)propane]nickel(II) chloride; In tetrahydrofuran; at 20 ℃; for 4h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.ejmech.2022.114226

upstream raw materials:

glycerol

2-propylaniline

8-bromoquinoline

1-(pyridin-2-yl)butan-1-one