903564-48-7

Base Information

• Chemical Name: 903564-48-7
• CAS No.: 903564-48-7
• Molecular Formula: C₃₀H₃₁F₃N₈O₃S
• Molecular Weight: 640.689
• Mol file: 903564-48-7.mol

Synonyms:

Chemical Property of 903564-48-7

Chemical Property:

• PKA: 11.40±0.70(Predicted)
• Density: 1.433±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

UM164 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 903564-48-7

There total 5 articles about 903564-48-7 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

1-(2-hydroxyethyl)piperazine (103-76-4) + 2-(6-chloro-2-methyl-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid [2-methyl-5-(3-trilfuoromethyl-benzoylamino)-phenyl]-amide → 2-{6-[4-(2-hydroxyethyl)-piperazin-1-yl]-2-methylpyrimidin-4-ylamino}-thiazole-5-carboxylic acid [2-methyl-5-(3-trifluoromethylbenzoylamino)-phenyl]-amide (903564-48-7)

Guidance literature:

In 1,4-dioxane; Reflux;

Reference yield:

2,4-dichloro-2-methylpyrimidine (1780-26-3) → 2-{6-[4-(2-hydroxyethyl)-piperazin-1-yl]-2-methylpyrimidin-4-ylamino}-thiazole-5-carboxylic acid [2-methyl-5-(3-trifluoromethylbenzoylamino)-phenyl]-amide (903564-48-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2.1: sodium hydroxide; water / methanol / 48 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.33 h / 0 - 20 °C

3.2: 20 °C

4.1: 1,4-dioxane / Reflux

With oxalyl dichloride; water; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate (1202357-66-1) → 2-{6-[4-(2-hydroxyethyl)-piperazin-1-yl]-2-methylpyrimidin-4-ylamino}-thiazole-5-carboxylic acid [2-methyl-5-(3-trifluoromethylbenzoylamino)-phenyl]-amide (903564-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 48 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.33 h / 0 - 20 °C

2.2: 20 °C

3.1: 1,4-dioxane / Reflux

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol;

upstream raw materials:

1-(2-hydroxyethyl)piperazine

2,4-dichloro-2-methylpyrimidine

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate

mononitro-p-xylene