2-amino-2'-isopropoxybiphenyl

Base Information

• Chemical Name: 2-amino-2'-isopropoxybiphenyl
• CAS No.: 142505-64-4
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.306
• Mol file: 142505-64-4.mol

Synonyms:

Chemical Property of 2-amino-2'-isopropoxybiphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-2'-isopropoxybiphenyl

There total 7 articles about 2-amino-2'-isopropoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-nitro-2'-isopropoxybiphenyl (142505-56-4) → 2-amino-2'-isopropoxybiphenyl (142505-64-4)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; for 6h; Heating;

DOI:10.1016/S0040-4020(01)88480-5

Reference yield: 81.0%

N-benzylidene-2-bromobenzenamine (15110-95-9) + 2-isopropoxyphenylmagnesium bromide → 2-amino-2'-isopropoxybiphenyl (142505-64-4)

Guidance literature:

2-isopropoxyphenylmagnesium bromide; With titanium(IV) tetraethanolate; phenol; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

N-benzylidene-2-bromobenzenamine; With iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In tetrahydrofuran; toluene; at 20 - 78 ℃; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.joc.9b00151

Reference yield: 65.0%

N-benzylidene-2-chloroaniline (884-29-7) + 2-isopropoxyphenylmagnesium bromide → 2-amino-2'-isopropoxybiphenyl (142505-64-4)

Guidance literature:

2-isopropoxyphenylmagnesium bromide; With titanium(IV) tetraethanolate; phenol; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

N-benzylidene-2-chloroaniline; With iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In tetrahydrofuran; toluene; at 20 - 78 ℃; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.joc.9b00151

upstream raw materials:

2-nitro-2'-isopropoxybiphenyl

4-iodoanisol

2'-nitro-[1,1'-biphenyl]-2-ol

2-methoxy-2'-nitrobiphenyl

Refernces

• 1、 Downie,Heaney,Kemp,King,Wosley. "Cyclisation reactions of 2-substituted biphenyl-2'-yldiazonium salts leading to O-alkyldibenzofuranium and S-alkyldibenzothiophenium salts: Modified Meerwein reagents". . p. 4005 - 4016. Retrieved 2007/10/02.