6-Chloro-4-ethoxynicotinic acid

Base Information

Chemical Name:6-Chloro-4-ethoxynicotinic acid
CAS No.:887572-34-1
Molecular Formula:C₈H₈ClNO₃
Molecular Weight:201.609
Hs Code.:29339900
DSSTox Substance ID:DTXSID90355859
Wikidata:Q72449935
Mol file:887572-34-1.mol

Synonyms:6-chloro-4-ethoxynicotinic acid;887572-34-1;6-chloro-4-ethoxypyridine-3-carboxylic acid;6-Chloro-4-ethoxy-nicotinic acid;6-Chloro-4-ethoxynicotinicacid;AC-907/34126044;SCHEMBL7866700;6-Chloro-4-ethoxy-nicotinicacid;DTXSID90355859;MFCD00834973;AKOS015851213;6-Chloro-4-ethoxynicotinic acid, 97%;AS-40827;CS-0312724;A861492;J-518563

Suppliers and Price of 6-Chloro-4-ethoxynicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-4-ethoxynicotinicAcid
25mg
$ 45.00

Frontier Specialty Chemicals
6-Chloro-4-ethoxynicotinicacid 97%
1g
$ 448.00

Crysdot
6-Chloro-4-ethoxynicotinicacid 95+%
5g
$ 734.00

Chemenu
6-Chloro-4-ethoxynicotinicacid 95%
5g
$ 693.00

Biosynth Carbosynth
6-Chloro-4-ethoxy-3-pyridinecarboxylic acid
500 mg
$ 265.00

Biosynth Carbosynth
6-Chloro-4-ethoxy-3-pyridinecarboxylic acid
250 mg
$ 117.50

Biosynth Carbosynth
6-Chloro-4-ethoxy-3-pyridinecarboxylic acid
100 mg
$ 97.00

Biosynth Carbosynth
6-Chloro-4-ethoxy-3-pyridinecarboxylic acid
50 mg
$ 60.50

Biosynth Carbosynth
6-Chloro-4-ethoxy-3-pyridinecarboxylic acid
1 g
$ 424.10

American Custom Chemicals Corporation
6-CHLORO-4-ETHOXYNICOTINIC ACID 95.00%
5MG
$ 496.75

Total 23 raw suppliers

Chemical Property of 6-Chloro-4-ethoxynicotinic acid

Chemical Property:

Vapor Pressure:9.63E-06mmHg at 25°C
Boiling Point:357.8±37.0 °C(Predicted)
PKA:3.25±0.10(Predicted)
Density:1.365±0.06 g/cm3 (20 oC 760 Torr)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:201.0192708
Heavy Atom Count:13
Complexity:188

Purity/Quality:

>97% ^*data from raw suppliers

6-Chloro-4-ethoxynicotinicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC(=NC=C1C(=O)O)Cl

Technology Process of 6-Chloro-4-ethoxynicotinic acid

There total 6 articles about 6-Chloro-4-ethoxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 73027-79-9
4,6-dichloro-nicotinic acid

: 141-52-6
sodium ethanolate

: 887572-34-1
2-chloro-4-ethoxypyridine-5-carboxylic acid

Guidance literature:: In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 18h;
DOI:10.1021/ml500137b

Reference yield:

: 40296-47-7
4-Ethoxy-6-chlor-nicotinsaeure-ethylester

: 887572-34-1
2-chloro-4-ethoxypyridine-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 0 ℃; for 1h;

Reference yield:

: 79398-27-9
methyl 4,6-dihydroxypyridine-3-carboxylate

: 887572-34-1
2-chloro-4-ethoxypyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 1.5 h / 90 °C

2: sodium hydroxide / water; tetrahydrofuran; methanol / 0.5 h / 20 °C

3: tetrahydrofuran; ethanol / 18 h / 0 - 20 °C

With sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/ml500137b