2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
• CAS No.: 345-28-8
• Molecular Formula: C9H7 F3 O3
• Molecular Weight: 220.148
• Hs Code.: 2918290000
• Mol file: 345-28-8.mol

Synonyms:2,4-Cresoticacid, a,a,a-trifluoro-, methyl ester (6CI,8CI); 4-Trifluoromethyl-2-hydroxybenzoicacid methyl ester; Methyl 2-hydroxy-4-(trifluoromethyl)benzoate; Methyl4-(trifluoromethyl)salicylate; NSC 408853

Chemical Property of 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0188mmHg at 25°C
• Boiling Point: 245°Cat760mmHg
• Flash Point: 102°C
• PSA: 46.53000
• Density: 1.382g/cm³
• LogP: 2.19760

Purity/Quality:

99%min ^*data from raw suppliers

2-Hydroxy-4-trifluromethylmethylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

There total 3 articles about 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

methanol (67-56-1) + 4-trifluoromethylsalicylic acid (328-90-5) → 2-hydroxy-4-trifluoromethylbenzoic acid methylester (345-28-8)

Guidance literature:

With chloro-trimethyl-silane; In toluene; for 12h; Reflux;

Reference yield: 80.0%

4-trifluoromethylsalicylic acid (328-90-5) + methyl iodide (74-88-4) → 2-hydroxy-4-trifluoromethylbenzoic acid methylester (345-28-8)

Guidance literature:

With lithium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.201402098

Reference yield:

→ 2-hydroxy-4-trifluoromethylbenzoic acid methylester (345-28-8)

Guidance literature:

upstream raw materials:

methanol

4-trifluoromethylsalicylic acid

methyl iodide

Downstream raw materials:

2-hydroxy-4-trifluoromethylbenzamide

2-hydroxy-4-trifluoromethyl-benzoic acid hydrazide

2-Hydroxy-N-(2-hydroxy-ethyl)-4-trifluoromethyl-benzamide

methyl 2-(3-(methoxycarbonyl)propanoxy)-4-trifluoromethyl benzoate

Refernces

• 1、 Takahashi, Hiroto,Nagashima, Yuki,Tanaka, Ken. "Rhodium(III)-Catalyzed Oxidative Intramolecular 1,1-Oxyamination of Alkenes with Protected Amino Acids to Produce Oxazoloisoindole-2,5-diones". supporting information. p. 1891 - 1895. Retrieved 2021/04/05.
• 2、 Kennedy, Andrew J.,Bruce, Alexandra M.,Gineste, Catherine,Ballard, T. Eric,Olekhnovich, Igor N.,Macdonald, Timothy L.,Hoffman, Paul S.. "Synthesis and antimicrobial evaluation of amixicile-based inhibitors of the pyruvate-ferredoxin oxidoreductases of anaerobic bacteria and Epsilonproteobacte". supporting information. p. 3980 - 3987. Retrieved 2016/07/11.