ethyl-(trans-2-amino-1-cyclohexanecarboxylate)hydrochloride

Base Information

• Chemical Name: ethyl-(trans-2-amino-1-cyclohexanecarboxylate)hydrochloride
• CAS No.: 1346773-57-6
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.7
• Mol file: 1346773-57-6.mol

Synonyms:

Chemical Property of ethyl-(trans-2-amino-1-cyclohexanecarboxylate)hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(1S,2R)-Ethyl2-aminocyclohexanecarboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-(trans-2-amino-1-cyclohexanecarboxylate)hydrochloride

There total 2 articles about ethyl-(trans-2-amino-1-cyclohexanecarboxylate)hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethanol (64-17-5) + (+/-)-trans-1,2-cyclohexanedicarboxylic anhydride (14166-21-3) → ethyl-(trans-2-amino-1-cyclohexanecarboxylate)hydrochloride (1127-99-7,28250-14-8,90950-07-5,180979-18-4,1346773-57-6)

Guidance literature:

(+/-)-trans-1,2-cyclohexanedicarboxylic anhydride; With trimethylsilylazide; In 1,4-dioxane; at 70 - 80 ℃; Heating;

With water; In 1,4-dioxane; at 0 ℃; for 0.166667h; Reflux;

ethanol; With hydrogenchloride; In 1,4-dioxane; water; for 2h; Reflux;

DOI:10.1021/jm301872x

Reference yield:

ethanol (64-17-5) + 1,2-cis-cyclohexanedicarboxylic anhydride (13149-00-3) → ethyl cis-2-amino-1-cyclohexanecarboxylate hydrochloride (1127-99-7,28250-14-8,90950-07-5,180979-18-4,1346773-57-6)

Guidance literature:

1,2-cis-cyclohexanedicarboxylic anhydride; With trimethylsilylazide; In 1,4-dioxane; Reflux;

ethanol; With hydrogenchloride; In 1,4-dioxane; water; Reflux;

DOI:10.1021/jm301872x

Reference yield:

(R)-1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (1620084-99-2) + (1S,2S)-ethyl 2-aminocyclohexanecarboxylate hydrochloride (180979-18-4,1346773-57-6) → (1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate (1620084-94-7)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

ethanol

(+/-)-trans-1,2-cyclohexanedicarboxylic anhydride

1,2-cis-cyclohexanedicarboxylic anhydride

Downstream raw materials:

(1R,2R)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate

(1R,2S)-ethyl 2-(1-(4’-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)cyclohexanecarboxylate