Propargyl-PEG13-acid

Base Information

• Chemical Name: Propargyl-PEG13-acid
• CAS No.: 1421676-62-1
• Molecular Formula: C₁₂H₂₀O₆
• Molecular Weight: 260.287
• Mol file: 1421676-62-1.mol

Synonyms:

Chemical Property of Propargyl-PEG13-acid

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

99.3% ^*data from raw suppliers

Propargyl-PEG14-acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG13-acid consists of an alkyne group and a carboxylic acid. The carboxylic acid reacts with amine groups to form amide bonds in the presence of EDC or HATU as an activator. The alkyne group is commonly used in copper catalyzed azide-alkyne Click Chemistry reactions. The hydrophilic PEG units enhance the solubility of the molecule in aqueous media.

Technology Process of Propargyl-PEG13-acid

There total 6 articles about Propargyl-PEG13-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate (1245823-50-0) → 4,7,10,13,16‐pentaoxanonadec‐18‐ynoic acid (1245823-51-1,1421676-62-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/c0cc00784f

Reference yield: 100.0%

tert-butyl 3-(2-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)ethoxy)propanoate (1355197-66-8) → 3-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]propanoic acid (1421676-62-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.chembiol.2019.05.010

Reference yield:

→ 4,7,10,13,16‐pentaoxanonadec‐18‐ynoic acid (1245823-51-1,1421676-62-1)

Guidance literature:

upstream raw materials:

tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate

tert-butyl 3-(2-(2-(2-(prop-2-ynyloxy)ethoxy)ethoxy)ethoxy)propanoate

O-propargyl triethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol