Tyr-Gly-Gly-Phe-Leu formate

Base Information

• Chemical Name: Tyr-Gly-Gly-Phe-Leu formate
• CAS No.: 100930-01-6
• Molecular Formula: CH₂O₂*C₂₈H₃₇N₅O₇
• Molecular Weight: 601.657
• Mol file: 100930-01-6.mol

Synonyms:

Chemical Property of Tyr-Gly-Gly-Phe-Leu formate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

LEUCINE ENKEPHALIN FORMATE SALT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tyr-Gly-Gly-Phe-Leu formate

There total 8 articles about Tyr-Gly-Gly-Phe-Leu formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

H-Gly-Gly-Phe-Leu-OBzl (69729-07-3) → Tyr-Gly-Gly-Phe-Leu formate (100930-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / KOAt / CHCl₃

2: H₂ / Pd / methanol; H₂O

With hydrogen; palladium; In methanol; chloroform; water; 1: Condensation / 2: Hydrogenolysis;

Reference yield:

(S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate (73994-89-5) → Tyr-Gly-Gly-Phe-Leu formate (100930-01-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / KOAt / CHCl₃

2: 84 percent / 4-AMP / CHCl₃

3: 80 percent / KOAt / CHCl₃

4: H₂ / Pd / methanol; H₂O

With hydrogen; palladium; In methanol; chloroform; water; 1: Condensation / 2: aminolysis / 3: Condensation / 4: Hydrogenolysis;

Reference yield:

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) → Tyr-Gly-Gly-Phe-Leu formate (100930-01-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 84 percent / KOAt / CHCl₃

2: 80 percent / 4-AMP / CHCl₃

3: 82 percent / KOAt / CHCl₃

4: 84 percent / 4-AMP / CHCl₃

5: 80 percent / KOAt / CHCl₃

6: H₂ / Pd / methanol; H₂O

With hydrogen; palladium; In methanol; chloroform; water; 1: Condensation / 2: aminolysis / 3: Condensation / 4: aminolysis / 5: Condensation / 6: Hydrogenolysis;

upstream raw materials:

formic acid

Fmoc-Tyr(Bzl)-Gly-Gly-Phe-Leu-OBzl

H-Gly-Gly-Phe-Leu-OBzl

L-phenylalanyl-L-leucine benzyl ester