C₁₆H₁₉BN₂O₂

Base Information

• Chemical Name: C₁₆H₁₉BN₂O₂
• CAS No.: 1319255-85-0
• Molecular Formula: C₁₆H₁₉BN₂O₂
• Molecular Weight: 282.15
• Mol file: 1319255-85-0.mol

Synonyms:

Chemical Property of C₁₆H₁₉BN₂O₂

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₉BN₂O₂

There total 3 articles about C₁₆H₁₉BN₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-phenyl-5-bromopyrimidine (38696-20-7) + bis(pinacol)diborane (73183-34-3) → C16H19BN2O2 (1319255-85-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

2-phenylpyrimidine (7431-45-0) + bis(pinacol)diborane (73183-34-3) → C16H19BN2O2 (1319255-85-0)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In hexane; at 20 ℃; for 24h; regioselective reaction; Glovebox;

DOI:10.1039/c4ob01565g

Reference yield:

phenylboronic acid (98-80-6) → C16H19BN2O2 (1319255-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.33 h / 120 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 16 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; In 1,4-dioxane;

upstream raw materials:

2-phenylpyrimidine

bis(pinacol)diborane

2-phenyl-5-bromopyrimidine

phenylboronic acid

Refernces

• 1、 -. "Organic compound based on pyridine and benzoxadiazole and application of the compound". Paragraph 0147-0149. . Retrieved 2020/03/17.