Methyl 3-(2-naphthyl)-2-propynoate

Base Information

Chemical Name:Methyl 3-(2-naphthyl)-2-propynoate
CAS No.:887572-51-2
Molecular Formula:C₁₄H₁₀O₂
Molecular Weight:210.232
Hs Code.:
European Community (EC) Number:840-184-7
Mol file:887572-51-2.mol

Synonyms:methyl 3-(2-naphthyl)-2-propynoate;methyl 3-naphthalen-2-ylprop-2-ynoate;Methyl 3-(naphthalen-2-yl)prop-2-ynoate;AKOS013858833;CS-0259932;EN300-7435174;AB-131/42301664;Z1235950590

Suppliers and Price of Methyl 3-(2-naphthyl)-2-propynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 3-(2-naphthyl)-2-propynoate

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:210.068079557
Heavy Atom Count:16
Complexity:320

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C#CC1=CC2=CC=CC=C2C=C1

Technology Process of Methyl 3-(2-naphthyl)-2-propynoate

There total 6 articles about Methyl 3-(2-naphthyl)-2-propynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 158053-33-9
methyl 3-naphthalen-2-yl-3-oxopropanoate

: 887572-51-2
methyl 3-(naphthalene-2-yl)-2-propynoate

Guidance literature:: methyl 3-naphthalen-2-yl-3-oxopropanoate; With lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; at -70 ℃; for 0.5h; Inert atmosphere;

With diethyl chlorophosphate; In tetrahydrofuran; ethylbenzene; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

With lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1139/cjc-2016-0181

Reference yield:

: 612-55-5
2-iodonaphthalene

: 922-67-8
propynoic acid methyl ester

: 887572-51-2
methyl 3-(naphthalene-2-yl)-2-propynoate

Guidance literature:: 2-iodonaphthalene; propynoic acid methyl ester; With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; for 0.0833333h;

With copper(l) iodide; In tetrahydrofuran; at 65 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b03082

Reference yield:

: 79-22-1
methyl chloroformate

: 218902-65-9
2-(2,2-dibromo-vinyl)-naphthalene

: 887572-51-2
methyl 3-(naphthalene-2-yl)-2-propynoate

Guidance literature:: 2-(2,2-dibromo-vinyl)-naphthalene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16h;
DOI:10.1021/acs.orglett.9b01132