5-bromo-2-chloro-N-methylbenzamide

Base Information

Chemical Name:5-bromo-2-chloro-N-methylbenzamide
CAS No.:435273-54-4
Molecular Formula:C₈H₇BrClNO
Molecular Weight:248.507
Hs Code.:
DSSTox Substance ID:DTXSID90428870
Wikidata:Q82241706
ChEMBL ID:CHEMBL4975318
Mol file:435273-54-4.mol

Synonyms:5-bromo-2-chloro-N-methylbenzamide;435273-54-4;METHYL 5-BROMO-2-CHLOROBENZAMIDE;SCHEMBL3819641;CHEMBL4975318;DTXSID90428870;CHEMBRDG-BB 7782157;MFCD05853706;AKOS001236593;SB77150;BS-23630;CS-0213204;FT-0683452;A872691;Z30272327

Suppliers and Price of 5-bromo-2-chloro-N-methylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl5-bromo-2-chlorobenzamide
500mg
$ 65.00

ChemBridge Corporation
5-bromo-2-chloro-N-methylbenzamide 95%
5 g
$ 133.00

American Custom Chemicals Corporation
5-BROMO-2-CHLORO-N-METHYLBENZAMIDE 95.00%
1G
$ 158.55

Alichem
5-Bromo-2-chloro-N-methylbenzamide
100g
$ 333.00

AK Scientific
Methyl5-bromo-2-chlorobenzamide
5g
$ 131.00

Total 10 raw suppliers

Chemical Property of 5-bromo-2-chloro-N-methylbenzamide

Chemical Property:

Vapor Pressure:0.000778mmHg at 25°C
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:246.93995
Heavy Atom Count:12
Complexity:176

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-bromo-2-chlorobenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C1=C(C=CC(=C1)Br)Cl

Technology Process of 5-bromo-2-chloro-N-methylbenzamide

There total 2 articles about 5-bromo-2-chloro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 74-89-5
methylamine

: 435273-54-4
5-bromo-2-chloro-N-methylbenzamide

Guidance literature:: 5-bromo-2-chlorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

methylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h;

Reference yield:

: 21900-52-7
5-bromo-2-chloro-benzoyl chloride

: 74-89-5
methylamine

: 435273-54-4
5-bromo-2-chloro-N-methylbenzamide

Guidance literature:: In tetrahydrofuran; methanol; at 0 - 20 ℃; for 2h;

Reference yield:

: 435273-54-4
5-bromo-2-chloro-N-methylbenzamide

: ethyl 4-{7-amino-3-[4-chloro-3-(methylcarbamoyl)phenyl]-2-methylpyrazolo[1,5-a]-pyrimidin-5-yl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 8.5 h / 90 - 120 °C / Inert atmosphere; Sealed tube

2.2: 1.5 h / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water;