(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid

Base Information

• Chemical Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid
• CAS No.: 1481642-14-1
• Molecular Formula: C₂₁H₂₁NO₆
• Molecular Weight: 383.401
• Mol file: 1481642-14-1.mol

Synonyms:

Chemical Property of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid

There total 1 articles about (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

L-glutamic acid 5-methyl ester (1499-55-4) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid (1481642-14-1)

Guidance literature:

L-glutamic acid 5-methyl ester; With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃; for 1.5h; Reflux;

(fluorenylmethoxy)carbonyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 58.3%

Fmoc-L-Arg-OH (91000-69-0,130752-32-8) + Fmoc-Lys(Mmt)-OH (159857-60-0) + (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid (1481642-14-1) + C38H35N5O6(2-)*Cl(1-)*Fe(3+) → C126H147N25O15(2-)*Cl(1-)*Fe(3+)

Guidance literature:

Multistep reaction;

DOI:10.1023/A:1022132331160

Reference yield:

(S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid (1481642-14-1) → 9-methylene-fluorene (4425-82-5) + (S)-2-[{({9H-fluoren-9-yl}methoxy)carbonyl}amino]pentanedioic acid (104091-09-0,136083-74-4,121343-82-6)

Guidance literature:

(S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid; With Barlos chlorotrityl resin;

With potassium trimethylsilonate; In dichloromethane; for 2h;

With scavenger TIPS; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2005.01.115

upstream raw materials:

L-glutamic acid 5-methyl ester

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

9-methylene-fluorene

(S)-2-[{({9H-fluoren-9-yl}methoxy)carbonyl}amino]pentanedioic acid