3-(2,5-difluorophenyl)pyridine

Base Information

• Chemical Name: 3-(2,5-difluorophenyl)pyridine
• CAS No.: 426823-29-2
• Molecular Formula: C₁₁H₇F₂N
• Molecular Weight: 191.18
• Mol file: 426823-29-2.mol

Synonyms:

Chemical Property of 3-(2,5-difluorophenyl)pyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(2,5-Difluorophenyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,5-difluorophenyl)pyridine

There total 3 articles about 3-(2,5-difluorophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-iodopyridine (1120-90-7) + para-difluorobenzene (540-36-3) → 3-(2,5-difluorophenyl)pyridine (426823-29-2)

Guidance literature:

With 1,10-Phenanthroline; potassium tert-butylate; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2015.06.010

Reference yield: 23.0%

phenyl nicotinate (3468-53-9) + 2,5-difurorboronic acid (193353-34-3) → 3-(2,5-difluorophenyl)pyridine (426823-29-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; caesium carbonate; tricyclohexylphosphine; In toluene; for 24h; Inert atmosphere; Glovebox; Reflux;

DOI:10.1002/ejoc.201500630

Reference yield:

nicotinic acid (59-67-6) → 3-(2,5-difluorophenyl)pyridine (426823-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 18 h / 20 °C

1.2: 24 h / 20 °C

2.1: tricyclohexylphosphine; caesium carbonate; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾ / toluene / 24 h / Inert atmosphere; Glovebox; Reflux

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; thionyl chloride; caesium carbonate; tricyclohexylphosphine; In toluene;

DOI:10.1002/ejoc.201500630

upstream raw materials:

phenyl nicotinate

2,5-difurorboronic acid

nicotinic acid

3-iodopyridine