1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine

Base Information

• Chemical Name: 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine
• CAS No.: 2244614-14-8
• Molecular Formula: C₂₅H₃₂FN₅O₂
• Molecular Weight: 453.56
• Mol file: 2244614-14-8.mol

Synonyms:

Chemical Property of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine

Chemical Property:

• Boiling Point: 649.8±65.0 °C(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

BTRX-335140 99.71% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine

There total 14 articles about 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-aminotetrahydropyran (38041-19-9) + 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperidin-4-one → 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine (2244614-14-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

5-(2-chloro-6-ethyl-8-fluoro-4-methylquinolin-3-yl)-3-methyl-1,2,4-oxadiazole → 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine (2244614-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 110 °C

2: sulfuric acid / tetrahydrofuran; water / 2 h / 45 °C

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With sulfuric acid; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane;

Reference yield:

1-(2-amino-5-ethyl-3-fluorophenyl)ethanone → 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine (2244614-14-8)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / 110 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 110 °C

3: sulfuric acid / tetrahydrofuran; water / 2 h / 45 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With sulfuric acid; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane;

upstream raw materials:

2-(3-methyl-1,2,4-oxadiazol-5-yl)acetic acid

4-aminotetrahydropyran

3-fluoroanthranilic acid

2-amino-5-bromo-3-fluorobenzoic acid