Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate

Base Information

Chemical Name:Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate
CAS No.:72850-71-6
Molecular Formula:C₆H₃ClF₃NO₂S
Molecular Weight:245.61
Hs Code.:
DSSTox Substance ID:DTXSID60534553
Wikidata:Q82408451

Synonyms:Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate;72850-71-6;Methyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate;SCHEMBL10820861;DTXSID60534553;ZLJWAOMXZUZJNG-UHFFFAOYSA-N;Methyl2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate

Suppliers and Price of Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 95+%
1g
$ 672.00

Chemenu
methyl2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 95%
1g
$ 635.00

Alichem
Methyl2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate
1g
$ 601.70

Total 1 raw suppliers

Chemical Property of Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:244.9525117
Heavy Atom Count:14
Complexity:238

Purity/Quality:: Methyl2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(N=C(S1)Cl)C(F)(F)F

Technology Process of Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate

There total 5 articles about Methyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: 72850-62-5
2-chloro-4-(trifluoromethyl)-5-thiazolecarbonyl chloride

: 72850-71-6
Methyl-2-chlor-4-trifluormethyl-5-thiazolcarboxylat

Guidance literature:: for 6h; Heating;

Reference yield:

: 72850-53-4
ethyl 2,3-dihydro-2-oxo-4-trifluoromethyl-5-thiazole-carboxylate

: 72850-71-6
Methyl-2-chlor-4-trifluormethyl-5-thiazolcarboxylat

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / POCl₃ / Heating

2: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature

3: 98 percent / SOCl₂ / 6 h / Heating

4: 95 percent / 6 h / Heating

With sodium hydroxide; thionyl chloride; trichlorophosphate; In tetrahydrofuran;

Reference yield:

: 72850-52-3
ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate

: 72850-71-6
Methyl-2-chlor-4-trifluormethyl-5-thiazolcarboxylat

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature

2: 98 percent / SOCl₂ / 6 h / Heating

3: 95 percent / 6 h / Heating

With sodium hydroxide; thionyl chloride; In tetrahydrofuran;