C₁₃H₂₃ClO₄

Base Information

• Chemical Name: C₁₃H₂₃ClO₄
• CAS No.: 521974-00-5
• Molecular Formula: C₁₃H₂₃ClO₄
• Molecular Weight: 278.776

Synonyms:

Chemical Property of C₁₃H₂₃ClO₄

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

tert-Butyl2-((4S,6S)-6-(chloromethyl(02,2-1,3-dioxan-4-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: tert-Butyl 2-((4S,6S)-6-(chloromethyl(02,2-1,3-dioxan-4-yl)acetate is an impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.

Technology Process of C₁₃H₂₃ClO₄

There total 15 articles about C₁₃H₂₃ClO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-dimethoxy-propane (77-76-9) + 1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate (154026-93-4) → (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester (154026-94-5,521973-99-9,521974-00-5,521974-01-6)

Guidance literature:

With camphor-10-sulfonic acid; In acetone; at 25 ℃; for 1.5h;

DOI:10.1002/1521-3765(20011105)7:21<4562::AID-CHEM4562>3.0.CO;2-4

Reference yield: 81.0%

(4R-cis)-(6-Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-yl-acetic Acid, Sodium Salt (391218-18-1) + tert-butyl alcohol (75-65-0) → (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester (154026-94-5,521973-99-9,521974-00-5,521974-01-6)

Guidance literature:

(4R-cis)-(6-Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-yl-acetic Acid, Sodium Salt; With 1-methyl-pyrrolidin-2-one; oxalyl dichloride; In toluene; at 20 - 25 ℃; for 6h;

tert-butyl alcohol; With 4-methyl-morpholine; In toluene; for 1h;

With sodium hydroxide; In water; toluene; at 40 ℃; for 1.5h;

Reference yield: 80.3%

2-(6-chloromethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid + isobutene (115-11-7,15220-85-6) → C13H23ClO4 (521974-00-5,521974-01-6)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -80 ℃; for 6h;

upstream raw materials:

2,2-dimethoxy-propane

1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate

tert-butyl (5S)-6-chloro-3,5-dihydroxyhexanoate

tert-butyl acetoacetate

Downstream raw materials:

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

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