di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

Base Information

• Chemical Name: di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate
• CAS No.: 174497-80-4
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.408
• Mol file: 174497-80-4.mol

Synonyms:

Chemical Property of di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-Tetrahydro-pyridazine-1,2,3-tricarboxylicacid1,2-di-tert-butylester3-methylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate

There total 17 articles about di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-(2,2,2-trichloro-ethyl) ester → (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (222556-21-0,174497-80-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 24h;

Reference yield: 96.0%

methanol (67-56-1) + (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-(2,2,2-trichloro-ethyl) ester → (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (222556-21-0,174497-80-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield: 92.0%

di-tert-butyl 3-methyl-1,2,3,6-tetrahydropyridazine-1,2,3-tricarboxylate (1161000-95-8) → di-tert-butyl 3-methyl hexahydropyridazine-1,2,3-tricarboxylate (1161001-03-1,174497-80-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 - 3800.26 Torr;

DOI:10.3987/COM-08-S(D)31

upstream raw materials:

diazomethane

(3R)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid

(4R)-3-<(3R)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone

N,N'-di-tert-butoxycarbonylpiperazic acid