ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS No.:327055-71-0
Molecular Formula:C₂₆H₂₅BrN₂O₆S
Molecular Weight:573.464
Hs Code.:
Mol file:327055-71-0.mol

ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

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Chemical Property of ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

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Technology Process of ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

There total 3 articles about ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

: 130333-46-9
5-bromo-2, 4-dimethoxybenzaldehyde

: 113697-57-7
5-(ethoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione

: 79-11-8
chloroacetic acid

: 327055-71-0
(Z)-ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Guidance literature:: With sodium acetate; acetic acid; In acetic anhydride; for 10h; Reflux;
DOI:10.1016/j.bmc.2014.07.037

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 327055-71-0
(Z)-ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol

2: sodium acetate; acetic acid / acetic anhydride / 10 h / Reflux

With hydrogenchloride; sodium acetate; acetic acid; In ethanol; acetic anhydride; 1: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.bmc.2014.07.037

Reference yield:

: 141-97-9
ethyl acetoacetate

: 327055-71-0
(Z)-ethyl 2-(5-bromo-2,4-dimethoxybenzylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol

2: sodium acetate; acetic acid / acetic anhydride / 10 h / Reflux

With hydrogenchloride; sodium acetate; acetic acid; In ethanol; acetic anhydride; 1: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.bmc.2014.07.037