dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate

Base Information

• Chemical Name: dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate
• CAS No.: 101497-18-1
• Molecular Formula: C₁₅H₂₀N₂O₆
• Molecular Weight: 324.334
• Mol file: 101497-18-1.mol

Synonyms:

Chemical Property of dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate

There total 3 articles about dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) → dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate (101497-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; ammonium acetate / 6 h / Reflux

2: 4C₂₆H₁₈N₈O₂S₃^(4-)*4Ni⁽²⁺⁾*8C₃H₇NO*0.5O₄S^(2-)*9H⁽¹⁺⁾; triethylamine / toluene / 48 h / 25 °C

With ammonium acetate; 4C₂₆H₁₈N₈O₂S₃^(4-)*4Ni⁽²⁺⁾*8C₃H₇NO*0.5O₄S^(2-)*9H⁽¹⁺⁾; acetic acid; triethylamine; In toluene; 2: |Michael Addition;

DOI:10.1039/c6dt04299f

Reference yield:

1-nitro-2-(4'-dimethylaminophenyl)ethene (2604-08-2) + sodiodimethylmalonate (18424-76-5) → dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate (101497-18-1)

Guidance literature:

With methanol;

Reference yield:

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline (22568-06-5) + malonic acid dimethyl ester (108-59-8) → dimethyl 2-(1-(4-(dimethylamino)phenyl)-2-nitroethyl)malonate (101497-18-1)

Guidance literature:

With 4C₂₆H₁₈N₈O₂S₃^(4-)*4Ni⁽²⁺⁾*8C₃H₇NO*0.5O₄S^(2-)*9H⁽¹⁺⁾; triethylamine; In toluene; at 25 ℃; for 48h; Reagent/catalyst; Kinetics;

DOI:10.1039/c6dt04299f

upstream raw materials:

1-nitro-2-(4'-dimethylaminophenyl)ethene

sodiodimethylmalonate

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline

malonic acid dimethyl ester