L-Ascorbic Acid 2-(Dihydrogen Phosphate) CyclohexanaMine-13C6

Base Information

• Chemical Name: L-Ascorbic Acid 2-(Dihydrogen Phosphate) CyclohexanaMine-13C6
• CAS No.: 82134-96-1
• Molecular Formula: C₆H₉O₉P*3C₆H₁₃N
• Molecular Weight: 553.634
• Mol file: 82134-96-1.mol

Synonyms:

Chemical Property of L-Ascorbic Acid 2-(Dihydrogen Phosphate) CyclohexanaMine-13C6

Chemical Property:

Purity/Quality:

L-AscorbicAcid2-(DihydrogenPhosphate)Cyclohexanamine-13C6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Isotope Labelled L-Ascorbic Acid 2-(Dihydrogen Phosphate) Cyclohexanamine is a derivative of L-Ascorbic Acid (A786990), an coenzyme for a number of hydroxylation reactions; required for collagen synthesis.

Technology Process of L-Ascorbic Acid 2-(Dihydrogen Phosphate) CyclohexanaMine-13C6

There total 2 articles about L-Ascorbic Acid 2-(Dihydrogen Phosphate) CyclohexanaMine-13C6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,5,6-tetrakis-O-(trimethylsilyl) ascorbate (55517-56-1) → tricyclohexylammonium salt of L-ascorbic acid 2-O-phosphate (82134-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Br₂, 2.) dimethyl phosphonate / 1.) CH₂Cl₂, room temperature, 1 h, 2.) room temperature, overnight

2: 1.) TMSP / 1.) 105 deg C, 5 h, 2.) ether, CH₃OH, room temperature to 0 deg C

With Tris(trimethylsilyl) phosphate; bromine; Dimethyl phosphite;

DOI:10.1021/jo00139a014

Reference yield:

(3aR,6S,6aR)-3a,6-Bis-trimethylsilanyloxy-tetrahydro-furo[3,2-b]furan-2,3-dione (82134-97-2) + cyclohexylamine (108-91-8,157973-60-9) → tricyclohexylammonium salt of L-ascorbic acid 2-O-phosphate (82134-96-1)

Guidance literature:

With Tris(trimethylsilyl) phosphate; Yield given. Multistep reaction; 1.) 105 deg C, 5 h, 2.) ether, CH₃OH, room temperature to 0 deg C;

DOI:10.1021/jo00139a014

upstream raw materials:

(3aR,6S,6aR)-3a,6-Bis-trimethylsilanyloxy-tetrahydro-furo[3,2-b]furan-2,3-dione

cyclohexylamine

2,3,5,6-tetrakis-O-(trimethylsilyl) ascorbate

Refernces