55517-56-1

Upstream product

• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 50-81-7 ascorbic acid 

Downstream Products

• 82134-96-1 tricyclohexylammonium salt of L-ascorbic acid 2-O-phosphate 

Relevant academic research and scientific papers

ORGANOSILOXANES CONTAINING ESTER DERIVATIVES OF ASCORBIC ACID

Organosiloxanes containing ester derivatives of ascorbic acid are disclosed having the formula (RiSiO)11Ro-Ii)Si-X- A wherein R is an alkyl group containing 1 to 6 carbon atoms, n is I to 3 inclusive, X is a divalent organic linking group, A is an ester derivati ve of ascorbic acid. A method of making an organosiloxane containing ester derivatives of ascorbic acid and the products prepared according to the method arc also taught. The compounds and compositions of the present disclosure are useful to affect tissue lightening when applied topically to keratinaceous tissue.

Ester Derivatives of Ascorbic and 2-Keto Acid Saccharides

Novel ester derivatives of ascorbic acid and 2-keto-acid saccharides are provided wherein the ester is introduced by ester bond formation between at least one hydroxy-functionality on the ascorbic acid or 2-keto-acid saccharide and a carboxy-functional organosiloxane, or between a 2-keto-gulonic acid and a hydroxy-functional organosiloxane, as well as methods for their synthesis. Treatment, cosmetic, and personal care formulations comprising the novel esters are also provided, including controlled release forms thereof.

Method for synthesis of silylated ascorbic acid derivatives

A compound of Formula (I), as defined in the specification, and a method for its synthesis. The method includes providing an inert environment, minimizing exposure of the reaction environment to visible light and reacting ascorbic acid with solvent and a compound of the Formula (II), as defined in the specification. The method of the present invention produces increased yields and a compound having increased stability and the same or greater bioactivity than ascorbic acid. The compound formed by the method of the present invention is capable for use in anhydrous cosmetic, dermatological and pharmaceutical compositions as an active agent for combating aging of the skin and improving its aesthetic appearance.

Silyl Phosphites. 21. A New Method for the Synthesis of L-Ascorbic Acid 2-O-Phosphate by Utilizing Phosphoryl Rearrangement

A stabilized form of vitamin C, L-ascorbic acid 2-O-phosphate (1), was successfully synthesized by a new method via a fully trimethylsilylated L-ascorbic acid (4) that was prepared in high yield by silylation of L-ascorbic acid with hexamethyldisilazane.Bromination of 4 gave an adduct (6) that was isomerized during distillation to a trimethylsilylated bicyclic half acetal (8) of dehydroascorbic acid.Addition of tris(trimethylsilyl) phosphite (TMSP) to 8 gave carbonyl addition compounds 9a and 9b, which underwent thermal rearrangement to give a mixture of bis(trimethylsilyl)-3,5,6-tris-O-(trimethylsilyl)-L-ascorbic acid 2-O-phosphate (10) and its 3-O-isomer 13 in the ratio of 88:12.Treatment of the mixture with cyclohexylamine in methanol gave selectively tricyclohexylammonium salt of L-ascorbic acid 2-O-phosphate in 53percent yield.