Technology Process of 2,3,5,6-Tetrakis-O-(trimethylsilyl)-L-ascorbic acid
There total 1 articles about 2,3,5,6-Tetrakis-O-(trimethylsilyl)-L-ascorbic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,1,1,3,3,3-hexamethyl-disilazane; ascorbic acid;
trifluorormethanesulfonic acid;
In
tetrahydrofuran;
at 66 - 70 ℃;
for 6h;
With
calcium carbonate;
In
tetrahydrofuran;
for 2h;
With
1,1,1,3,3,3-hexamethyl-disilazane;
at 70 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) Br2, 2.) dimethyl phosphonate / 1.) CH2Cl2, room temperature, 1 h, 2.) room temperature, overnight
2: 1.) TMSP / 1.) 105 deg C, 5 h, 2.) ether, CH3OH, room temperature to 0 deg C
With
Tris(trimethylsilyl) phosphate; bromine; Dimethyl phosphite;
DOI:10.1021/jo00139a014
