Technology Process of N-[3-cyano-4-(2,2,2-trifluoroethyl)phenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide
There total 10 articles about N-[3-cyano-4-(2,2,2-trifluoroethyl)phenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / Ice cooling
2: iron; ammonium chloride / ethanol; water / 0.83 h / 65 °C / Heating / reflux
3: pyridine / 1 h / Cooling with ice
With
iron; sodium hydride; ammonium chloride;
In
pyridine; DMF (N,N-dimethyl-formamide); ethanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: benzenesulfonyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 - 145 °C
2: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / Ice cooling
3: iron; ammonium chloride / ethanol; water / 0.83 h / 65 °C / Heating / reflux
4: pyridine / 1 h / Cooling with ice
With
iron; sodium hydride; ammonium chloride; benzenesulfonyl chloride;
In
pyridine; DMF (N,N-dimethyl-formamide); ethanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 5 h / 20 °C / Heating / reflux
2: sodium hydroxide; potassium permanganate / pyridine; DMF (N,N-dimethyl-formamide) / 3 h / 20 °C / Ice cooling
3: thionyl chloride / 1,2-dichloro-ethane / 0.5 h / 83 - 110 °C
4: pyridine / 1 h / Cooling with ice
With
sodium hydroxide; potassium permanganate; thionyl chloride; trifluorormethanesulfonic acid;
In
pyridine; DMF (N,N-dimethyl-formamide); 1,2-dichloro-ethane;
