2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan

Base Information

• Chemical Name: 2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan
• CAS No.: 1451182-98-1
• Molecular Formula: C₂₁H₁₅FO₂
• Molecular Weight: 318.347
• Mol file: 1451182-98-1.mol

Synonyms:

Chemical Property of 2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan

There total 2 articles about 2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethynyl-4-fluorobenzene (766-98-3) + 2,4-dichlorophenol (120-83-2,40477-79-0) → 2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan (1451182-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloro bis(acetonitrile) palladium(II); C₃₁H₃₆O₂*BF₄^(1-)*H⁽¹⁺⁾; lithium tert-butoxide / toluene / 0.25 h / 20 °C / Inert atmosphere

1.2: 0.75 h / Inert atmosphere; Reflux

1.3: 2 h / Inert atmosphere; Reflux

2.1: potassium phosphate / toluene; water / 6 h / Inert atmosphere; Reflux

With dichloro bis(acetonitrile) palladium(II); potassium phosphate; C₃₁H₃₆O₂*BF₄^(1-)*H⁽¹⁺⁾; lithium tert-butoxide; In water; toluene; 1.1: |Sonogashira Cross-Coupling / 1.3: |Suzuki-Miyaura Coupling / 2.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/jo401503t

Reference yield:

5-chloro-2-(4-fluorophenyl)benzo[b]furan (1448818-03-8) + 4-methoxyphenylboronic acid (5720-07-0) → 2-(4-fluorophenyl)-5-(4-methoxyphenyl)benzo[b]furan (1451182-98-1)

Guidance literature:

With potassium phosphate; In water; toluene; for 6h; Inert atmosphere; Reflux;

DOI:10.1021/jo401503t

upstream raw materials:

1-ethynyl-4-fluorobenzene

2,4-dichlorophenol

5-chloro-2-(4-fluorophenyl)benzo[b]furan

4-methoxyphenylboronic acid