(R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid

Base Information

• Chemical Name: (R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid
• CAS No.: 127526-57-2
• Molecular Formula: C₂₄H₂₈Cl₂N₂O₆
• Molecular Weight: 511.402
• Mol file: 127526-57-2.mol

Synonyms:

Chemical Property of (R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid

There total 1 articles about (R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methyl-N-(benzyloxycarbonyl)-D-leucine (65635-85-0) + (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate (127526-62-9) → (R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid (127526-57-2)

Guidance literature:

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF-THF, 0 deg C to room t., 14 h, 2.) MeOH, room temp., 30 min;

DOI:10.1016/S0040-4039(01)93850-X

Reference yield:

3,5-diiodo-4-hydroxy-D-phenylglycine methyl ester (127526-63-0) + (R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid (127526-57-2) → C37H40Cl2IN5O10 (127526-59-4)

Guidance literature:

Multistep reaction;

DOI:10.1016/S0040-4039(01)93850-X

upstream raw materials:

N-methyl-N-(benzyloxycarbonyl)-D-leucine

(R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate

Downstream raw materials:

C₃₇H₄₀Cl₂IN₅O₁₀