(R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate

Base Information

• Chemical Name: (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate
• CAS No.: 127526-62-9
• Molecular Formula: C₁₀H₁₁Cl₂NO₃
• Molecular Weight: 264.108
• Mol file: 127526-62-9.mol

Synonyms:(R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate

Chemical Property of (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate

There total 2 articles about (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (R)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid (15924-16-0) → (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate (127526-62-9)

Guidance literature:

With thionyl chloride; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02729

Reference yield:

tyrosine (556-02-5,18875-48-4,25619-78-7,30704-25-7) → (R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate (127526-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sulfuryl dichloride / 5 h / 20 °C / Inert atmosphere

2: thionyl chloride / 20 °C / Inert atmosphere

With thionyl chloride; sulfuryl dichloride; acetic acid;

DOI:10.1021/acs.orglett.6b02729

Reference yield: 79.0%

(R)-methyl 2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoate (127526-62-9) + chloromethyl methyl ether (107-30-2) → C12H15Cl2NO4

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c7cc00469a

upstream raw materials:

methanol

(R)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid

tyrosine

Downstream raw materials:

(R)-2-[(R)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid

(R)-2-((R)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid

C₆₇H₇₀Cl₄N₈O₁₇

C₆₇H₇₁Cl₄IN₈O₁₇