2,3,5-Trifluoroanisole

Base Information

• Chemical Name: 2,3,5-Trifluoroanisole
• CAS No.: 4920-36-9
• Molecular Formula: C₇H₅F₃O
• Molecular Weight: 162.111
• DSSTox Substance ID: DTXSID001302374
• Nikkaji Number: J3.359.239F
• Mol file: 4920-36-9.mol

Synonyms:2,3,5-Trifluoroanisole;4920-36-9;1,2,5-trifluoro-3-methoxybenzene;SCHEMBL10086105;DTXSID001302374;C90786

Chemical Property of 2,3,5-Trifluoroanisole

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 162.02924926
• Heavy Atom Count: 11
• Complexity: 131

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C(=CC(=C1)F)F)F

Technology Process of 2,3,5-Trifluoroanisole

There total 4 articles about 2,3,5-Trifluoroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,5-tetrafluorobenzene (2367-82-0) + sodium methylate (124-41-4) → 2,3,6-trifluoro-4-methoxybenzene (4920-36-9)

Guidance literature:

In methanol;

DOI:10.1016/S0022-1139(00)82583-X

Reference yield:

1,2,3,5-tetrafluorobenzene (2367-82-0) → 2,3,6-trifluoro-4-methoxybenzene (4920-36-9)

Guidance literature:

With sodium methylate; In methanol; at -58 ℃; Rate constant;

Reference yield:

methanol (67-56-1) + 1,2,3,5-tetrafluorobenzene (2367-82-0) → 2,3,6-trifluoro-4-methoxybenzene (4920-36-9)

Guidance literature:

With ammonia; sodium; Yield given. Multistep reaction; 1.) -50 deg C, 2.) -50 to -40 deg C, 7 h.;

upstream raw materials:

methanol

1,2,3,5-tetrafluorobenzene

sodium methylate