4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:142638-91-3
Molecular Formula:C15H27NO4
Molecular Weight:285.37900
Hs Code.:
European Community (EC) Number:871-546-2
Mol file:142638-91-3.mol

Synonyms:142638-91-3;4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester;5-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]pentanoic acid;5-(1-(tert-Butoxycarbonyl)piperidin-4-yl)pentanoic acid;SCHEMBL4474447;IGAMPJQATITLPV-UHFFFAOYSA-N;AMY21072;AKOS034082524;N-BOC-5-(4-piperidyl)pentanoic acid;AT11275;EN300-333132;5-(1-(tert-Butoxycarbonyl)piperidin-4-yl)pentanoicacid;Z1508691483;5-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}pentanoic acid

Suppliers and Price of 4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
4-(4-Carboxy-butyl)-piperidine-1-carboxylicacidtert-butylester
250mg
$ 538.00

Total 1 raw suppliers

Chemical Property of 4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

PSA：66.84000
LogP:3.21640
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:285.19400834
Heavy Atom Count:20
Complexity:327

Purity/Quality:: 4-(4-Carboxy-butyl)-piperidine-1-carboxylicacidtert-butylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)CCCCC(=O)O

Technology Process of 4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 8 articles about 4-(4-Carboxy-butyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1305383-46-3
methyl 5-(4-piperidyl)pentanoate

: 142638-91-3
5-(1-t-Butoxycarbonyl-4-piperidyl)pentanoic acid

Guidance literature:: With potassium hydrogensulfate; In sodium hydroxide;

Reference yield:

: 498-94-2
isonipecotic acid

: 142638-91-3
5-(1-t-Butoxycarbonyl-4-piperidyl)pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

2: 65 percent / Et₃N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature

3: 87 percent / LiAlH₄ / tetrahydrofuran / 5 h / Ambient temperature

4: CHCl₃ / 16 h / Heating

5: H₂ / 10percent Pd/C / methanol / 24 h / 2844.3 Torr

6: aq. NaOH / methanol / 0.5 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9801096

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 142638-91-3
5-(1-t-Butoxycarbonyl-4-piperidyl)pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

2: 65 percent / Et₃N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature

3: 87 percent / LiAlH₄ / tetrahydrofuran / 5 h / Ambient temperature

4: CHCl₃ / 16 h / Heating

5: H₂ / 10percent Pd/C / methanol / 24 h / 2844.3 Torr

6: aq. NaOH / methanol / 0.5 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9801096