Technology Process of 2-Pyrrolidinone, 5-(azidomethyl)-, (5S)-
There total 1 articles about 2-Pyrrolidinone, 5-(azidomethyl)-, (5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen azide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; benzene;
a) -10 deg C, 30 min, b) 0 deg C, 2 h, c) RT, overnight;
DOI:10.1016/S0957-4166(00)86019-X
- Guidance literature:
-
(+)-(S)-5-(azidomethyl)-2-pyrrolidone;
With
trimethoxonium tetrafluoroborate;
In
dichloromethane;
for 4.5h;
Inert atmosphere;
phenylhydrazine;
In
dichloromethane;
for 3h;
Inert atmosphere;
trimethyl orthoformate;
In
methanol; dichloromethane;
at 80 ℃;
for 20h;
DOI:10.1055/s-0029-1219543
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 60 mg / tetrahydrofuran / -78 - 20 °C
2.1: LiHMDS / tetrahydrofuran / 0.67 h / -78 °C
2.2: Davis oxaziridine / tetrahydrofuran / 3 h / -78 °C
3.1: 270 mg / imidazole / dimethylformamide
4.1: TBAF; AcOH / tetrahydrofuran
5.1: aq. LiOH / tetrahydrofuran / 0.08 h / 0 °C
6.1: DCC / ethyl acetate / 96 h / 0 °C
7.1: tetrahydrofuran; H2O / 72 h
8.1: aq. NH3 / tetrahydrofuran / 10 h / 20 °C
9.1: H2 / 10 percent Pd/C / dioxane; H2O; acetic acid / 2 h
With
1H-imidazole; lithium hydroxide; ammonium hydroxide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)01625-3
